Novel quinolin-2-yl nitrones useful for the prevention and/or treatment of neurodegenerative diseases


Alzheimer’s disease is a neurodegenerative disease characterized by progressive deterioration of memory and learning ability due to a variety of pathological changes in the central nervous system. Parkinson’s disease is a chronic neurodegenerative disease characterized by the progressive death of dopaminergic neurons. Due to the aging of the population, both diseases place an increasing burden on patients’ families and healthcare systems. New therapeutic options are needed to mitigate the consequences of neurodegenerative diseases and improve the quality of life not only for patients but also for their families.

Description of the invention

The invention relates to quinolin-2-yl nitrones having formula I, which can be used as drugs for the treatment of neurodegenerative diseases by inhibiting butyrylcholinesterase and monoamine oxidase B either alone or in combination with other beneficial activities, such as antioxidant properties and metal chelation. The present invention is being tested in animal models of neurodegenerative diseases, and our goal is to further develop it for human application.

Main advantages

Drugs developed for the treatment of Alzheimer’s and Parkinson’s diseases usually have low activity and cause severe undesirable side effects. Our drug candidates act through different and innovative mechanisms of action that may provide better therapy and limit side effects.

Developed by

University of Ljubljana,
Faculty of Pharmacy


Get in touch with us

Solutions to your challenges

More information

We use cookies (necessary, analytical and marketing) to ensure the proper functioning of our website and to improve your user experience. Click on “customize settings” to manage your preferences. For more detailed information, please check our Cookie Policy .

Guide to knowledge transfer at the University of Ljubljana.

Read more